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ELISA kit ("sandwich" type) for the quantitative determination of follicle-stimulating hormone in human serum.
Follicle-stimulating hormone (FSH) is a glycoprotein with molecular weight ca. 30 000 Da consisting of two subunits, alpha and beta. FSH is secreted by frontal lobe of pituitary gland.
Together with LH and testosterone, FSH is vitally important for spermatogenesis in spermatic ducts of testicles. In pubescent females FSH induces follicle growth and maturation in ovaries. Increased FSH levels are observed in patients with different forms of hypogonadism (primary ovary or testicle insufficiency, polycystic ovaries, menopause etc), renal insufficiency, cirrhosis or aftereffect of castration. As a rule, decreased FSH levels are observed in case of testicle malignancies.
FSH measurement is useful for diagnosis of menopause, exact determination of ovulation time and for endocrine therapy monitoring.