Neonatal TSH

REF 23-01

ELISA kit ("sandwich" type) for the quantitative determination of thyroid-stimulating hormone in dry spots of newborns’ blood.

Thyroid-stimulating hormone (TSH) is a glycoprotein hormone with molecular weight ca.  30 000 Da, consisting of two subunits,  i.e. alpha and beta. TSH is secreted by the frontal lobe of hypophysis and stimulates synthesis of thyroxin and triiodothyronine in the thyroid gland.

Abrupt  increase of TSH concentration in blood is detected in newborns just after their birth. If the newborn’s thyroid gland function is normal, TSH concentration decreases within several days after birth and then stays  stable at the normal level (< 20 µIU/ml of blood). The increased THS concentration in blood of newborns on 3rd-5th day of life is the earliest diagnostic indicator of congenital primary hypothyroidism.